About Summit:

Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational

bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD-1 and VEGF.

Summit has begun its clinical development of ivonescimab in non-small cell lung cancer (NSCLC), with three active Phase III trials:

• HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib).

• HARMONi-3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

• HARMONi-7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC whose tumors have high PD-L1 expression.

Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting.

Overview of Role:

Summit Therapeutics is seeking an experienced and dynamic Medical Affairs Director to lead the development and implementation of medical strategies for ivonescimab targeting different solid tumor cancers. This role will involve close collaboration with cross-functional teams, including clinical development, regulatory affairs, and commercial operations, to support the investigation and eventual commercialization of ivonescimab in different indications. The ideal candidate is able to demonstrate effective planning and execution of medical affairs strategies leading to a successful development or adoption of an oncology therapy, as well as ability to analyze, summarize, and deliver complex scientific data to a multitude of audiences.

Overview of Role:

The Medical Science Liaison (MSL) is a field-based scientific expert specializing in Immuno-Oncology and related treatment options. They play a strategic role in supporting Summit’s scientific and business objectives throughout the oncology product lifecycle. MSLs act as the primary scientific communicators for Summit within their designated regions, engaging with healthcare professionals and supporting clinical site activities.

Combining strong business acumen, clinical expertise, and market awareness, MSLs serve as vital conduits of information to various stakeholders within Summit. Depending on therapeutic needs and product life cycles, their responsibilities may include clinical development and pipeline support.

Role and Responsibilities:

• Develop, execute, and maintain high-impact territory plans, including HCP and Investigator engagement plans, aligned with therapeutic area medical and scientific objectives, focusing on quality
• Identify, gain access to, and develop professional, customer-centric relationships with external experts in Immuno-Oncology within the assigned geography
• Provide education on disease state, therapeutic landscape, and Summit’s products across the product lifecycle to healthcare providers and researchers.
• Support clinical development, clinical operations, and research initiatives, including site evaluation and identification, recruitment, investigator meetings, external expert identification, and involving experts to generate scientific data, including investigator-sponsored trials
• Participate, monitor, and provide insights to Summit from relevant scientific meetings within the relevant geography
• Continuously maintain self-education on market issues and trends, product knowledge, and new therapeutic areas of interest, creating awareness and relationships for Summit in the medical community
• Create, maintain, and collaborate on relationships with cross-functional partnerships to develop and execute account plans designed to support and meet shared scientific or business objectives
• Actively participate in relevant team meetings, organizational activities, and country-driven medical affairs activities (e.g., advisory boards, Masterclasses, Round-tables)
• All other duties as assigned

Experience, Education and Specialized Knowledge and Skills:

• Doctoral degree in health sciences from an accredited university (MD, PhD, PharmD, or equivalent). Significant clinical and/or industry experience in the oncology therapeutic area may be accepted in lieu of education requirements.
• Lung Cancer clinical experience within the last 5 years is highly desired
• A minimum of 5+ years of clinical, scientific/research, or industry-related experience or equivalent is preferred
• A minimum of 2+ years experience as a Medical Science Liaison is require
• Previous pharmaceutical industry experience within a relevant scientific discipline is preferred.
• Language requirements:
  • Proficiency in English is required
  • Fluency in Turkish or Greek highly desired
• The MSL must possess and demonstrate past achievements in:
  • Understanding, analyzing, and communicating complicated scientific concepts and data
  • Building credible relationships with prominent HCPs
  • Independently identifying and translating corporate needs into action plans that achieve objectives
  • Self-motivation to achieve and exceed goals
  • Problem-solving and analytic skills
  • Critical thinking
  • Ability to work independently
• Other essential requirements:
  • Meeting healthcare industry representative (HCIR) credentialing requirements to enter facilities and organizations within the assigned territory. These may include background checks, drug screens, and proof of immunization/vaccination for various diseases.
  • Willingness to travel up to 75% of the time
  • Proficiency in using the standard MS Office suite (e.g., Word, Excel), electronic document management systems, and document review tools
  • Strong computer and database skills
  • Attention to detail, accuracy, and confidentiality
  • Clear and concise oral and written communication skills
  • Excellent organizational skills
  • Ability to effectively multi-task or adapt quickly to changing priorities
  • Ability to manage time-sensitive and highly confidential documents
  • Ability to prioritize conflicting demands
  • Ability to work in a fast-paced, demanding, and collaborative environment